It's not "Calorie Restriction" that's healthy...

Folks,

I recently encountered an interesting study that suggests that 
glucose restriction is the reason classic calorie restriction 
has health and life extending benefits...

The study:
----------------------------------------------------------------

	Glucose restriction extends healthy cellular life span

Writing in an article published online on December 2009 in FASEB 
Journal, researchers at the University of Alabama at Birmingham 
(UAB) reveal that restricting glucose, a common dietary sugar 
that is used by the cells for energy, results in extended life 
for healthy cells and growth inhibition and programmed cell 
death of precancerous cells.

University of Alabama Department of Biology professor Trygve 
Tollefsbol, PhD, DO and colleagues cultured healthy and 
precancerous human lung cells with normal or significantly 
restricted glucose for several weeks. "In that time, we were 
able to track the cells' ability to divide while also monitoring 
the number of surviving cells," Dr Tollefsbol reported. "The 
pattern that was revealed to us showed that restricted glucose 
levels led the healthy cells to grow longer than is typical and 
caused the precancerous cells to die off in large numbers."

Dr Tollefsbol and his associates found that while there was an 
increase in the expression of the human telomerase reverse 
transcriptase gene and a decrease in the expression of the 
anticancer protein p16 in normal glucose restricted cells, 
opposite effects were observed in precancerous cells that were 
glucose-restricted. "The healthy cells saw their telomerase rise 
and p16 decrease, which would explain the boost in healthy cell 
growth," Dr Tollefsbol noted. "The gene reactions flipped in the 
precancerous cells with telomerase decreasing and the anticancer 
protein p16 increasing, which would explain why these cancer-
forming cells died off in large numbers."

"Our results not only support previous findings from the feeding 
of animals but also reveal that human longevity can be achieved 
at the cellular level through caloric restriction," he added. 
"The hope is that this UAB breakthrough will lead to further 
discoveries in different cell types and facilitate the 
development of novel approaches to extend the lifespan of 
humans."

----------------------------------------------------------------

I expect to spend the balance of my life obtaining the bulk of 
my daily calories from fat rather than from carbohydrate. It's 
more and more clear that carbohydrate -- which is just glucose 
molecules strung together -- is unhealthy for us in so many 
different ways.

-- 
________________________________________________________________
Steve.   / Longest Repeated Strings: http://www.grc.com/dev/LRS/
0
Steve
7/6/2012 5:01:04 PM
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On Fri, 6 Jul 2012 10:01:04 -0700, Steve Gibson <news07_@_grc.com> wrote:

> Folks,
> 
> I recently encountered an interesting study that suggests that 
> glucose restriction is the reason classic calorie restriction 
> has health and life extending benefits...

If we eat nothing, we die now.
If we eat lots, we die soon.
If we eat little, we die later.

One way or another, food kills us!

-- 
tbl
0
tbl
7/6/2012 9:58:01 PM
Thanks for the info Steve. I've always wondered how the calorie=20
restriction science fits in with everything else I know about nutrition.=20
The only question I have is how significant is the telomerase change=20
(with everything we know from Dr. Rosedale)?

I too plan to spend much of my life in ketosis and don't find it too=20
difficult. But I can understand if some do.

P.S. I'm eagerly awaiting news on the Ketoflute?
0
simpsons
7/7/2012 10:49:49 PM
[for the unabridged version, see simpsons's post above]

> Thanks for the info Steve. I've always wondered how the calorie
> restriction science fits in with everything else I know about
> nutrition.  The only question I have is how significant is the
> telomerase change (with everything we know from Dr. Rosedale)?

Telomeres, as we know, are one of a number of competing theories 
of aging.  And it makes sense.  My feeling is that probably 
"everyone" is right to varying degrees.  But my own personal #1 
favorite theory from among the many is long-term mitochondrial 
corruption and degradation occurring over time as we age due to 
the fact that mitochondrial DNA lacks the self-repairing system 
that nuclear (the cell's nucleus) DNA has.  This results in our 
cells individually and collectively slowly "losing power" and 
thus being less able to perform their individual specific 
functions.

And, of course, the RATE of corruption of mitochondrial DNA is a 
function of the presence of life-long anti-corruption defenses 
and lowered pro-corruption influences.


> I too plan to spend much of my life in ketosis and don't
> find it too difficult. But I can understand if some do.

Exactly.  I'm fine with it too for the long term.  Getting here 
was moderately hellish, and adaptation took a full ten weeks for 
me.  But now I'm no longer even needing to consume high-sodium 
bullion for water balance.  My kidneys finally adapted, though 
they were slow to do so.


> P.S. I'm eagerly awaiting news on the Ketoflute?

Me too!  I have some next-generation gas sensors currently 
burning in on my lab bench that I'm VERY ANXIOUS to get tested. 
They require a week of "settling time". But that project, which 
is still on the top of the stack, did get pushed onto the stack 
by my need to spend some necessary time with SpinRite marketing.

EVERYTHING I am allowed to do is fueled and made possible ONLY 
by SpinRite's amazing continuing sales against all odds.  And 
the INSTANT school got out and the summer began we saw a 
seasonal slow down in sales.  So I'm working to do what I can in 
the short term to close a higher percentage of the people who 
come to GRC to consider SpinRite.  Based upon the effects I have 
already seen, I believe that the creation of a compelling 
tutorial about hard disks and SpinRite will help a lot.

Once that's in place I plan to get back to research on the 
ketoflute.  :)

-- 
________________________________________________________________
Steve.   / Longest Repeated Strings: http://www.grc.com/dev/LRS/
0
Steve
7/8/2012 4:36:52 PM
On 08/07/12 17:36, Steve Gibson wrote:
> ... <snip>
>
> EVERYTHING I am allowed to do is fueled and made possible ONLY
> by SpinRite's amazing continuing sales against all odds.  And
> the INSTANT school got out and the summer began we saw a
> seasonal slow down in sales.  So I'm working to do what I can in
> the short term to close a higher percentage of the people who
> come to GRC to consider SpinRite.  Based upon the effects I have
> already seen, I believe that the creation of a compelling
> tutorial about hard disks and SpinRite will help a lot.
>
> Once that's in place I plan to get back to research on the
> ketoflute.  :)
>
I expect most of us realise that Spinrite finances everything you do for 
our community, which is so huge that we're all living off the back of it 
to some extent. I continually marvel at the things you come up with - so 
besides my (genuinely) altruistic wish for your well being, I have a 
selfish interest in your pursuit of longevity for yourself and your 
finances. Whatever you have to do to prolong Spinrite sales must be an 
essential top priority - an immutable given. And I guess you're going to 
have to work on version 7 soon to make it work with UEFI. Your comment 
in SN358 on its usefulness regarding solid state drives was most 
encouraging as I thought this technology was outside Spinrite's scope. 
Hopefully this will stretch its life even further. Here's to Spinrite.

And I'm also hoping that the ketoflute will be successful. I'm back in 
ketosis with my wife and we will be on the list for purchase if and when 
this is available.

0
Russell
7/9/2012 7:00:44 AM
On 2012-07-06 17:01:04 +0000, Steve Gibson said:

> Folks,
> 
> I recently encountered an interesting study that suggests that
> glucose restriction is the reason classic calorie restriction
> has health and life extending benefits...
> 
> The study:
> ----------------------------------------------------------------

Yeah.

As I understand it, not eating too much protein may also be crucial.  I 
haven't followed the references up, but Dr. Rosedale has spoken to this.

So has Nora Gedgaudas (who seems to have connections with Rosedale.)  
Actually I think it's partly for this reason that Nora describes her 
book _Primal Body, Primal Mind_ as "going beyond the Paleo Diet".  The 
Paleo Diet is, of course, a high-protein diet.  Here's what she says on 
her site:

"Suffice it to say that this newly discovered metabolic pathway,  
“mTOR”, apparently serves as a sort of metabolic “protein sensor”. It 
belongs to something called the “P13K” pathway that is activated by 
insulin, nutrients and growth factors. It turns out that keeping mTOR 
down-regulated–by limiting protein intake to what is simply necessary 
for maintenance–is actually part of the key to maximizing our internal 
repair and regeneration, immune function–enhancing longevity, 
anti-aging and minimizing the risk of cancer. "

<http://www.primalbody-primalmind.com/?p=295>

Professor Cordain recommends up to 30% of calories as protein, IIRC.  
Dr. Rosedale suggests 1 gram per kg of lean body mass, which on an 
intake of around 2500 kcals is going to be something more like 10 or 
15% of calories.  That's a *lot* less.

What Paleolthic Man actually ate is anyone's guess - Cordain uses 
figures on modern hunter-gatherers (and a lot of assumptions) - but 
Paeolithic Man wasn't exactly worried about longevity anyway.

Judging by ethnographic reports he would have known to select the 
fattiest parts of animal carcases (something Cordain seems reluctant to 
acknowledge - though less so recently).  Even so he wasn't out to eat 
the minimum protein necessary.

Cheers,

Mike

0
LCHF
7/10/2012 8:28:16 PM
Reply:

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